We analyze the different parametrizations of a general four-zero texture mass matrices for quarks and leptons, that are able to reproduce the CKM and PMNS mixing matrices. This study is done through a Chi-Square analysis. In quark sector, only four solutions are found to be compatible with CKM mixing matrix. In leptonic sector, using the last experimental results about the mixing angles in the neutrino sector, our Chi-Square analysis shows a preferred value for m_nu_3 to be around 0.05 eV independently of the parametrization of the four-zero texture mass matrices chosen for the charged leptons and neutrinos.