In this paper we study the renormalization effects of the quark flavor mixings and the Higgs self- coupling in a five dimensional model where the boson fields are propagating in the bulk whilst the matter fields are localized to the brane. We first explore the evolution behaviors for the Cabibbo- Kobayashi-Maskawa matrix in this scenario. Then, in light of the recent LHC bounds on the Higgs mass, we find that the Higgs self-coupling evolution has an improved vacuum stability condition, which is in contrast with that of Standard Model and the Universal Extra Dimension scenario, where the theory has a much lower ultraviolet cut-off.
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