Contamination from instrumental effects interacting with bright astrophysical sources is the primary impediment to measuring Epoch of Reionization and BAO 21 cm power spectra---an effect called mode-mixing. In this paper we identify four fundamental power spectrum shapes produced by mode-mixing that will affect all upcoming observations. We are able, for the first time, to explain the wedge-like structure seen in advanced simulations and to forecast the shape of an EoR window that is mostly free of contamination. Understanding the origins of these contaminations also enables us to identify calibration and foreground subtraction errors below the imaging limit, providing a powerful new tool for precision observations.