Methods of extraction of the symmetry energy (or enthalpy) coefficient to temperature ratio from isobaric and isotopic yields of fragments produced in Fermi-energy heavy-ion collisions are discussed. We show that the methods are consistent when the hot fragmenting source is well characterized and its excitation energy and isotopic composition are properly taken into account. The results are independent of the mass number of the detected fragments, which suggests that their fate is decided very early in the reaction.