Based on time-dependent radiation-hydrodynamics simulations of the evolution of Planetary Nebulae (PNe), we have carried out a systematic parameter study to address the non-trivial question of how the diffuse X-ray emission of PNe with closed central cavities is expected to depend on the evolutionary state of the nebula, the mass of the central star, and the metallicity of stellar wind and circumstellar matter. We have also investigated how the model predictions depend on the treatment of thermal conduction at the interface between the central `hot bubble and the `cool inner nebula, and compare the results with recent X-ray observations. Our study includes models whose properties resemble the extreme case of PNe with Wolf-Rayet type central stars. Indeed, such models are found to produce the highest X-ray luminosities.