We consider the possibility that dark matter can communicate with the Standard Model fields via flavor interactions. We take the dark matter to belong to a dark sector which contains at least two types, or flavors, of particles and then hypothesize that the Standard Model fields and dark matter share a common interaction which depends on flavor. As, generically, interaction eigenstates and mass eigenstates need not coincide, we consider both flavor-changing and flavor-conserving interactions. These interactions are then constrained by meson decays, kaon mixing, and current collider bounds, and we examine their relevance for direct detection and LHC.