We have used the Spitzer Space Telescope to obtain Multiband Imaging Photometer for Spitzer (MIPS) 24 um photometry for 37 members of the ~100 Myr old open cluster Blanco 1. For the brightest 25 of these stars (where we have 3sigma uncertainties less than 15%), we find significant mid-IR excesses for eight stars, corresponding to a debris disk detection frequency of about 32%. The stars with excesses include two A stars, four F dwarfs and two G dwarfs. The most significant linkage between 24 um excess and any other stellar property for our Blanco 1 sample of stars is with binarity. Blanco 1 members that are photometric binaries show few or no detected 24 um excesses whereas a quarter of the apparently single Blanco 1 members do have excesses. We have examined the MIPS data for two other clusters of similar age to Blanco 1 -- NGC 2547 and the Pleiades. The AFGK photometric binary star members of both of these clusters also show a much lower frequency of 24 um excesses compared to stars that lie near the single-star main sequence. We provide a new determination of the relation between V-Ks color and Ks-[24] color for main sequence photospheres based on Hyades members observed with MIPS. As a result of our analysis of the Hyades data, we identify three low mass Hyades members as candidates for having debris disks near the MIPS detection limit.
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