4-dimensional locally CAT(0)-manifolds with no Riemannian smoothings

We construct examples of smooth 4-dimensional manifolds M supporting a locally CAT(0)-metric, whose universal cover X satisfy Hruskas isolated flats condition, and contain 2-dimensional flats F with the property that the boundary at infinity of F defines a nontrivial knot in the boundary at infinity of X. As a consequence, we obtain that the fundamental group of M cannot be isomorphic to the fundamental group of any Riemannian manifold of nonpositive sectional curvature. In particular, M is a locally CAT(0)-manifold which does not support any Riemannian metric of nonpositive sectional curvature.