Normal subgroups of diffeomorphism and homeomorphism groups of R^n and other open manifolds

We determine all the normal subgroups of the group of C^r diffeomorphisms of R^n, r = 1,2,...,infinity, except when r=n+1 or n=4, and also of the group of homeomorphisms of R^n (r=0). We also study the group A_0 of diffeomorphisms of an open manifold M that are isotopic to the identity. If M is the interior of a compact manifold with nonempty boundary, then the quotient of A_0 by the normal subgroup of diffeomorphisms that coincide with the identity near to a given end e of M is simple.