We analyze the $5sigma$ difference between the CP asymmetries of the $B^0 to K^+ pi^-$ and $B^+ to K^+ pi^0$ decays within the Soft Collinear Effective Theory. We find that in the Standard Model, such a big difference cannot be achieved. We classify then the requirements for the possible New Physics models, which can be responsible for the experimental results. As an example of a New Physics model we study minimal supersymmetric models, and find that the measured asymmetry can be obtained with non-minimal flavor violation.