We discuss a common feature of all known reactions on nuclear targets - a significant suppression at large x. Simple interpretation of this effect is based on energy conservation restrictions in initial state parton rescatterings. Using the light-cone dipole approach this mechanism is shown to control variety of processes on nuclear targets: high-pT particle production at different rapidities as well as direct and virtual (Drell-Yan) photon production. We demonstrate universality and wide applicability of this mechanism allowing to describe large-x effects also at SPS and FNAL energies too low for the onset of coherent effects or shadowing.
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