The Open Science Grid (OSG) includes work to enable new science, new scientists, and new modalities in support of computationally based research. There are frequently significant sociological and organizational changes required in transformation from the existing to the new. OSG leverages its deliverables to the large scale physics experiment member communities to benefit new communities at all scales through activities in education, engagement and the distributed facility. As a partner to the poster and tutorial at SciDAC 2008, this paper gives both a brief general description and some specific examples of new science enabled on the OSG. More information is available at the OSG web site: (http://www.opensciencegrid.org).
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