We perform a series of high-resolution N-body simulations of cosmological structure formation starting from Gaussian and non-Gaussian initial conditions. We adopt the best-fitting cosmological parameters of WMAP (3rd- and 5th-year) and we consider non-Gaussianity of the local type parameterised by 8 different values of the non-linearity parameter F_NL. Building upon previous work based on the Gaussian case, we show that, expressed in terms of suitable variables, the mass function of friends-of-friends haloes is approximately universal (i.e. independent of redshift, cosmology, and matter transfer function) to good precision (nearly 10 per cent) also in non-Gaussian scenarios. We provide fitting formulae for the high-mass end (M>10^13 M_sol/h) of the universal mass function in terms of F_NL, and we also present a non-universal fit in terms of both F_NL and z to be used for applications requiring higher accuracy. In the Gaussian case, we extend our fit to a wider range of halo masses (M>2.4 x 10^10 M_sol/h) and we also provide a consistent fit of the linear halo bias. We show that, for realistic values of F_NL, the matter power-spectrum in non-Gaussian cosmologies departs from the Gaussian one by up to 2 per cent on the scales where the baryonic- oscillation features are imprinted on the 2-point statistics. We confirm the strong k-dependence of the halo bias on large scales (k<0.05 h Mpc^-1) which was already detected in previous studies. However, we find that commonly used parameterisations based on the peak-background split do not provide an accurate description of our simulations which present extra dependencies on the wavenumber, the non-linearity parameter and, possibly, the clustering strength. We provide an accurate fit of the simulation data that can be used as a benchmark for future determinations of F_NL with galaxy surveys.
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