We present the color-magnitude and color-stellar mass diagrams for galaxies with z_phot < ~2, based on a K < 22 (AB) catalog of the Extended Chandra Deep Field South (ECDFS) from the MUltiwavelength Survey by Yale-Chile (MUSYC). Our main sample of 7840 galaxies contains 1297 M_* > 10^11 M_Sol galaxies in the range 0.2 < z_phot < 1.8. We show empirically that this catalog is approximately complete for M_* > 10^11 M_Sol galaxies for z_phot < 1.8. For this mass-limited sample, we show that the locus of the red sequence color-stellar mass relation evolves as Del(u-r) ~ (-0.44+/-0.02) z_phot for z_phot < ~1.2. For z_phot > ~1.3, however, we are no longer able to reliably distinguish red and blue subpopulations from the observed color distribution; we show that this would require much deeper near infrared data. At 1.5 < z_phot <1.8, the comoving number density of M_* > 10^11 M_Sol galaxies is ~50% of the local value, with a red fraction of ~33%. Making a parametric fit to the observed evolution, we find n_tot(z) ~ (1+z_phot)^(-0.52+/-0.12(+/-0.20)). We find stronger evolution in the red fraction: f_red(z) ~ (1+z_phot)^(-1.17+/-0.18(+/-0.21)). Through a series of sensitivity analyses, we show that the most important sources of systematic error are: 1. systematic differences in the analysis of the z~0 and z>>0 samples; 2. systematic effects associated with details of the photometric redshift calculation; and 3. uncertainties in the photometric calibration. With this in mind, we show that our results based on photometric redshifts are consistent with a completely independent analysis which does not require redshift information for individual galaxies. Our results suggest that, at most, 1/5 of local red sequence galaxies with M_* >10^11 M_Sol were already in place at z ~ 2.
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