Spontaneous Unknotting of a Polymer Confined in a Nanochannel

We study the dynamics of a knot in a semiflexible polymer confined to a narrow channel of width comparable to the polymers persistence length. Using a combination of Brownian dynamics simulations and a coarse-grained stochastic model, we characterize the coupled dynamics of knot size variation and knot diffusion along the polymer, which ultimately leads to spontaneous unknotting. We find that the knot grows to macroscopic size before disappearing. Interestingly, an external force applied to the ends of the confined polymer speeds up spontaneous unknotting.