The unique Hamiltonian description of neuro- and psycho-dynamics at the macroscopic, classical, inter-neuronal level of brains neural networks, and microscopic, quantum, intra-neuronal level of brains microtubules, is presented in the form of open Liouville equations. This implies the arrow of time in both neuro- and psycho-dynamic processes and shows the existence of the formal neuro-biological space-time self-similarity. Keywords: Neuro- and psycho-dynamics, Brain microtubules, Hamiltonian and Liouville dynamics, Neuro-biological self-similarity