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Register a new userPoisson-Dirichlet Distribution with Small Mutation Rate
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Shui Feng
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The behavior of the Poisson-Dirichlet distribution with small mutation rate is studied through large deviations. The structure of the rate function indicates that the number of alleles is finite at the instant when mutation appears. The large deviation results are then used to study the asymptotic behavior of the homozygosity, and the Poisson-Dirichlet distribution with symmetric selection. The latter shows that several alleles can coexist when selection intensity goes to infinity in a particular way as the mutation rate approaches zero.
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The Poisson--Dirichlet distribution arises in many different areas. The parameter $theta$ in the distribution is the scaled mutation rate of a population in the context of population genetics. The limiting case of $theta$ approaching infinity is practically motivated and has led to new, interesting mathematical structures. Laws of large numbers, fluctuation theorems and large-deviation results have been established. In this paper, moderate-deviation principles are established for the Poisson--Dirichlet distribution, the GEM distribution, the homozygosity, and the Dirichlet process when the parameter $theta$ approaches infinity. These results, combined with earlier work, not only provide a relatively complete picture of the asymptotic behavior of the Poisson--Dirichlet distribution for large $theta$, but also lead to a better understanding of the large deviation problem associated with the scaled homozygosity. They also reveal some new structures that are not observed in existing large-deviation results.
The two parameter Poisson-Dirichlet distribution $PD(alpha,theta)$ is the distribution of an infinite dimensional random discrete probability. It is a generalization of Kingmans Poisson-Dirichlet distribution. The two parameter Dirichlet process $Pi_{alpha,theta, u_0}$ is the law of a pure atomic random measure with masses following the two parameter Poisson-Dirichlet distribution. In this article we focus on the construction and the properties of the infinite dimensional symmetric diffusion processes with respective symmetric measures $PD(alpha,theta)$ and $Pi_{alpha,theta, u_0}$. The methods used come from the theory of Dirichlet forms.
The two-parameter Poisson-Dirichlet distribution is the law of a sequence of decreasing nonnegative random variables with total sum one. It can be constructed from stable and Gamma subordinators with the two-parameters, $alpha$ and $theta$, corresponding to the stable component and Gamma component respectively. The moderate deviation principles are established for the two-parameter Poisson-Dirichlet distribution and the corresponding homozygosity when $theta$ approaches infinity, and the large deviation principle is established for the two-parameter Poisson-Dirichlet distribution when both $alpha$ and $theta$ approach zero.
Reversibility of the Fleming-Viot process with mutation, selection, and recombination is well understood. In this paper, we study the reversibility of a system of Fleming-Viot processes that live on a countable number of colonies interacting with each other through migrations between the colonies. It is shown that reversibility fails when both migration and mutation are non-trivial.
Let $A$ and $B$ be two $N$ by $N$ deterministic Hermitian matrices and let $U$ be an $N$ by $N$ Haar distributed unitary matrix. It is well known that the spectral distribution of the sum $H=A+UBU^*$ converges weakly to the free additive convolution of the spectral distributions of $A$ and $B$, as $N$ tends to infinity. We establish the optimal convergence rate ${frac{1}{N}}$ in the bulk of the spectrum.
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