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Register a new userThe waiting time for m mutations
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Jason Schweinsberg
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We consider a model of a population of fixed size N in which each individual gets replaced at rate one and each individual experiences a mutation at rate mu. We calculate the asymptotic distribution of the time that it takes before there is an individual in the population with m mutations. Several different behaviors are possible, depending on how mu changes with N. These results have applications to the problem of determining the waiting time for regulatory sequences to appear and to models of cancer development.
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