We study sequential programs that are instruction sequences with dynamically instantiated instructions. We define the meaning of such programs in two different ways. In either case, we give a translation by which each program with dynamically instantiated instructions is turned into a program without them that exhibits on execution the same behaviour by interaction with some service. The complexity of the translations differ considerably, whereas the services concerned are equally simple. However, the service concerned in the case of the simpler translation is far more powerful than the service concerned in the other case.