We calculate $pXi^0$ potentials from the equal-time Bethe-Salpeter amplitude measured in the quenched QCD simulation with the spatial lattice volume, (4.4 fm)$^3$. The standard Wilson gauge action with the gauge coupling $beta=5.7$ on $32^4$ lattice together with the standard Wilson quark action are used. The hopping parameter $kappa_{ud}=0.1678$ is chosen for $u$ and $d$ quarks, which corresponds to $m_{pi}simeq 0.37$ GeV. The physical strange quark mass is used by taking the parameter $kappa_s=0.1643$ which is deduced from the physical $K$ meson mass. The lattice spacing $a=0.1420$ fm is determined by the physical $rho$ meson mass. We find that the $pXi^0$ potential has strong spin dependence. Strong repulsive core is found in $^1S_0$ channel while the effective central potential in the $^3S_1$ channel has relatively weak repulsive core. The potentials also have weak attractive parts in the medium to long distance region (0.6 fm $lsim r lsim 1.2$ fm) in both of the $^1S_0$ and $^3S_1$ channels.
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