We introduce a new formalism of differential operators for a general associative algebra A. It replaces Grothendiecks notion of differential operator on a commutative algebra in such a way that derivations of the commutative algebra are replaced by DDer(A), the bimodule of double derivations. Our differential operators act not on the algebra A itself but rather on F(A), a certain `Fock space associated to any noncommutative algebra A in a functorial way. The corresponding algebra D(F(A)), of differential operators, is filtered and gr D(F(A)), the associated graded algebra, is commutative in some `twisted sense. The resulting double Poisson structure on gr D(F(A)) is closely related to the one introduced by Van den Bergh. Specifically, we prove that gr D(F(A))=F(T_A(DDer(A)), provided A is smooth. It is crucial for our construction that the Fock space F(A) carries an extra-structure of a wheelgebra, a new notion closely related to the notion of a wheeled PROP. There are also notions of Lie wheelgebras, and so on. In that language, D(F(A)) becomes the universal enveloping wheelgebra of a Lie wheelgebroid of double derivations. In the second part of the paper we show, extending a classical construction of Koszul to the noncommutative setting, that any Ricci-flat, torsion-free bimodule connection on DDer(A) gives rise to a second order (wheeled) differential operator, a noncommutative analogue of the BV-operator.
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