We evaluate heavy-quark (HQ) transport properties in a Quark-Gluon Plasma (QGP) employing interaction potentials extracted from thermal lattice QCD. Within a Brueckner many-body scheme we calculate in-medium T-matrices for charm- and bottom-quark scattering off light quarks in the QGP. The interactions are dominated by attractive meson and diquark channels which support bound and resonance states up to temperatures of ~1.5 T_c. We apply pertinent drag and diffusion coefficients (supplemented by perturbative scattering off gluons) in Langevin simulations in an expanding fireball to compute HQ spectra and elliptic flow in sqrt{s_{NN}}=200 GeV Au-Au collisions. We find good agreement with semileptonic electron-decay spectra which supports our nonperturbative computation of the HQ diffusion coefficient, suggestive for a strongly coupled QGP.
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