Typical astronomical spectrographs have a resolution ranging between a few hundred to 200.000. Deconvolution and correlation techniques are being employed with a significance down to 1/1000 th of a pixel. HeAr and ThAr lamps are usually used for calibration in low and high resolution spectroscopy, respectively. Unfortunately, the emitted lines typically cover only a small fraction of the spectrometers spectral range. Furthermore, their exact position depends strongly on environmental conditions. A problem is the strong intensity variation between different (intensity ratios {>300). In addition, the brightness of the lamps is insufficient to illuminate a spectrograph via an integrating sphere, which in turn is important to calibrate a long-slit spectrograph, as this is the only way to assure a uniform illumination of the spectrograph pupil. Laboratory precision laser spectroscopy has experienced a major advance with the development of optical frequency combs generated by pulsed femto-second lasers. These lasers emit a broad spectrum (several hundred nanometers in the visible and near infra-red) of equally-spaced comb lines with almost uniform intensity (intensity ratios typically <10). Self-referencing of the laser establishes a precise ruler in frequency space that can be stabilized to the 10e-18 uncertainty level, reaching absolute frequency inaccuracies at the 10e-12 level per day when using the Global Positioning Systems (GPS) time signal as the reference. The exploration of the merits of this new technology holds the promise for broad-band, highly accurate and reproducible calibration required for reliable operation of current and next generation astronomic spectrometers.