This paper introduces the notion of Rota-Baxter $C^{ast}$-algebras. Here a Rota-Baxter $C^{ast}$-algebra is a $C^{ast}$-algebra with a Rota-Baxter operator. Symmetric Rota-Baxter operators, as special cases of Rota-Baxter operators on $C^{ast}$-algebra, are defined and studied. A theorem of Rota-Baxter operators on concrete $C^{ast}$-algebras is given, deriving the relationship between two kinds of Rota-Baxter algebras. As a corollary, some connection between $ast$-representations and Rota-Baxter operators is given. The notion of representations of Rota-Baxter $C^{ast}$-algebras are constructed, and a theorem of representations of direct sums of Rota-Baxter representations is derived. Finally using Rota-Baxter operators, the notion of quasidiagonal operators on $C^{ast}$-algebra is reconstructed.
We study the sum of the finite multiple harmonic $q$-series on $rtext{-}(r+1)$ indices at roots of unity with $r=1,2,3$. And we give the equivalent conditions of two conjectures regarding cyclic sums of finite multiple harmonic $q$-series on $1text{-}2text{-}3$ indices at roots of unity, posed recently by Kh. Pilehrood, T. Pilehrood and R. Tauraso.
Mendelian randomization (MR) has become a popular approach to study causal effects by using genetic variants as instrumental variables. We propose a new MR method, GENIUS-MAWII, which simultaneously addresses the two salient phenomena that adversely affect MR analyses: many weak instruments and widespread horizontal pleiotropy. Similar to MR GENIUS citep{Tchetgen2019_GENIUS}, we achieve identification of the treatment effect by leveraging heteroscedasticity of the exposure. We then derive the class of influence functions of the treatment effect, based on which, we construct a continuous updating estimator and establish its consistency and asymptotic normality under a many weak invalid instruments asymptotic regime by developing novel semiparametric theory. We also provide a measure of weak identification and graphical diagnostic tool. We demonstrate in simulations that GENIUS-MAWII has clear advantages in the presence of directional or correlated horizontal pleiotropy compared to other methods. We apply our method to study the effect of body mass index on systolic blood pressure using UK Biobank.
Inference of population structure from genetic data plays an important role in population and medical genetics studies. The traditional EIGENSTRAT method has been widely used for computing and selecting top principal components that capture population structure information (Price et al., 2006). With the advancement and decreasing cost of sequencing technology, whole-genome sequencing data provide much richer information about the underlying population structures. However, the EIGENSTRAT method was originally developed for analyzing array-based genotype data and thus may not perform well on sequencing data for two reasons. First, the number of genetic variants $p$ is much larger than the sample size $n$ in sequencing data such that the sample-to-marker ratio $n/p$ is nearly zero, violating the assumption of the Tracy-Widom test used in the EIGENSTRAT method. Second, the EIGENSTRAT method might not be able to handle the linkage disequilibrium (LD) well in sequencing data. To resolve those two critical issues, we propose a new statistical method called ERStruct to estimate the number of latent sub-populations based on sequencing data. We propose to use the ratio of successive eigenvalues as a more robust testing statistic, and then we approximate the null distribution of our proposed test statistic using modern random matrix theory. Simulation studies found that our proposed ERStruct method has outperformed the traditional Tracy-Widom test on sequencing data. We further use two public data sets from the HapMap 3 and the 1000 Genomes Projects to demonstrate the performance of our ERStruct method. We also implement our ERStruct in a MATLAB toolbox which is now publicly available on GitHub through https://github.com/bglvly/ERStruct.
Mendelian randomization (MR) is a statistical method exploiting genetic variants as instrumental variables to estimate the causal effect of modifiable risk factors on an outcome of interest. Despite wide uses of various popular two-sample MR methods based on genome-wide association study summary level data, however, those methods could suffer from potential power loss or/and biased inference when the chosen genetic variants are in linkage disequilibrium (LD), and also have relatively large direct effects on the outcome whose distribution might be heavy-tailed which is commonly referred to as the idiosyncratic pleiotropy phenomenon. To resolve those two issues, we propose a novel Robust Bayesian Mendelian Randomization (RBMR) model that uses the more robust multivariate generalized t-distribution to model such direct effects in a probabilistic model framework which can also incorporate the LD structure explicitly. The generalized t-distribution can be represented as a Gaussian scaled mixture so that our model parameters can be estimated by the EM-type algorithms. We compute the standard errors by calibrating the evidence lower bound using the likelihood ratio test. Through extensive simulation studies, we show that our RBMR has robust performance compared to other competing methods. We also apply our RBMR method to two benchmark data sets and find that RBMR has smaller bias and standard errors. Using our proposed RBMR method, we find that coronary artery disease is associated with increased risk of critically ill coronavirus disease 2019 (COVID-19). We also develop a user-friendly R package RBMR for public use.
Standard Mendelian randomization analysis can produce biased results if the genetic variant defining the instrumental variable (IV) is confounded and/or has a horizontal pleiotropic effect on the outcome of interest not mediated by the treatment. We provide novel identification conditions for the causal effect of a treatment in presence of unmeasured confounding, by leveraging an invalid IV for which both the IV independence and exclusion restriction assumptions may be violated. The proposed Mendelian Randomization Mixed-Scale Treatment Effect Robust Identification (MR MiSTERI) approach relies on (i) an assumption that the treatment effect does not vary with the invalid IV on the additive scale; and (ii) that the selection bias due to confounding does not vary with the invalid IV on the odds ratio scale; and (iii) that the residual variance for the outcome is heteroscedastic and thus varies with the invalid IV. We formally establish that their conjunction can identify a causal effect even with an invalid IV subject to pleiotropy. MiSTERI is shown to be particularly advantageous in presence of pervasive heterogeneity of pleiotropic effects on additive scale, a setting in which two recently proposed robust estimation methods MR GxE and MR GENIUS can be severely biased. In order to incorporate multiple, possibly correlated and weak IVs, a common challenge in MR studies, we develop a MAny Weak Invalid Instruments (MR MaWII MiSTERI) approach for strengthened identification and improved accuracy MaWII MiSTERI is shown to be robust to horizontal pleiotropy, violation of IV independence assumption and weak IV bias. Both simulation studies and real data analysis results demonstrate the robustness of the proposed MR MiSTERI methods.
When estimating the relevancy between a query and a document, ranking models largely neglect the mutual information among documents. A common wisdom is that if two documents are similar in terms of the same query, they are more likely to have similar relevance score. To mitigate this problem, in this paper, we propose a multi-agent reinforced ranking model, named MarlRank. In particular, by considering each document as an agent, we formulate the ranking process as a multi-agent Markov Decision Process (MDP), where the mutual interactions among documents are incorporated in the ranking process. To compute the ranking list, each document predicts its relevance to a query considering not only its own query-document features but also its similar documents features and actions. By defining reward as a function of NDCG, we can optimize our model directly on the ranking performance measure. Our experimental results on two LETOR benchmark datasets show that our model has significant performance gains over the state-of-art baselines. We also find that the NDCG shows an overall increasing trend along with the step of interactions, which demonstrates that the mutual information among documents helps improve the ranking performance.
Hawkings calculation is unable to predict the final stage of the black hole evaporation. When effects of quantum gravity are taken into account, there is a minimal observable length. In this paper, we investigate fermions tunnelling from the charged and rotating black strings. With the influence of the generalized uncertainty principle, the Hawking temperatures are not only determined by the rings, but also affected by the quantum numbers of the emitted fermions. Quantum gravity corrections slow down the increases of the temperatures, which naturally leads to remnants left in the evaporation.
