We obtain $L_p$ estimates for fractional parabolic equations with space-time non-local operators $$ partial_t^alpha u - Lu= f quad mathrm{in} quad (0,T) times mathbb{R}^d,$$ where $partial_t^alpha u$ is the Caputo fractional derivative of order $alpha in (0,1]$, $Tin (0,infty)$, and $$Lu(t,x) := int_{ mathbb{R}^d} bigg( u(t,x+y)-u(t,x) - ycdot abla_xu(t,x)chi^{(sigma)}(y)bigg)K(t,x,y),dy $$ is an integro-differential operator in the spatial variables. Here we do not impose any regularity assumption on the kernel $K$ with respect to $t$ and $y$. We also derive a weighted mixed-norm estimate for the equations with operators that are local in time, i.e., $alpha = 1$, which extend the previous results by using a quite different method.
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