Despite the success of deep learning methods in medical image segmentation tasks, the human-level performance relies on massive training data with high-quality annotations, which are expensive and time-consuming to collect. The fact is that there exist low-quality annotations with label noise, which leads to suboptimal performance of learned models. Two prominent directions for segmentation learning with noisy labels include pixel-wise noise robust training and image-level noise robust training. In this work, we propose a novel framework to address segmenting with noisy labels by distilling effective supervision information from both pixel and image levels. In particular, we explicitly estimate the uncertainty of every pixel as pixel-wise noise estimation, and propose pixel-wise robust learning by using both the original labels and pseudo labels. Furthermore, we present an image-level robust learning method to accommodate more information as the complements to pixel-level learning. We conduct extensive experiments on both simulated and real-world noisy datasets. The results demonstrate the advantageous performance of our method compared to state-of-the-art baselines for medical image segmentation with noisy labels.
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