The abundance, distribution and inner structure of satellites of galaxy clusters can be sensitive probes of the properties of dark matter. We run 30 cosmological zoom-in simulations with self-interacting dark matter (SIDM), with a velocity-dependent cross-section, to study the properties of subhalos within cluster-mass hosts. We find that the abundance of subhalos that survive in the SIDM simulations are suppressed relative to their cold dark matter (CDM) counterparts. Once the population of disrupted subhalos -- which may host orphan galaxies -- are taken into account, satellite galaxy populations in CDM and SIDM models can be reconciled. However, even in this case, the inner structure of subhalos are significantly different in the two dark matter models. We study the feasibility of using the weak lensing signal from the subhalo density profiles to distinguish between the cold and self-interacting dark matter while accounting for the potential contribution of orphan galaxies. We find that the effects of self-interactions on the density profile of subhalos can appear degenerate with subhalo disruption in CDM, when orphans are accounted for. With current error bars from the Subaru Hyper Suprime-Cam Strategic Program, we find that subhalos in the outskirts of clusters (where disruption is less prevalent) can be used to constrain dark matter physics. In the future, the Vera C. Rubin Observatory Legacy Survey of Space and Time will give precise measurements of the weak lensing profile and can be used to constrain $sigma_T/m$ at the $sim 1$ cm$^2$ g$^{-1}$ level at $vsim 2000$ km s$^{-1}$.
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