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Biomedical knowledge graphs permit an integrative computational approach to reasoning about biological systems. The nature of biological data leads to a graph structure that differs from those typically encountered in benchmarking datasets. To understand the implications this may have on the performance of reasoning algorithms, we conduct an empirical study based on the real-world task of drug repurposing. We formulate this task as a link prediction problem where both compounds and diseases correspond to entities in a knowledge graph. To overcome apparent weaknesses of existing algorithms, we propose a new method, PoLo, that combines policy-guided walks based on reinforcement learning with logical rules. These rules are integrated into the algorithm by using a novel reward function. We apply our method to Hetionet, which integrates biomedical information from 29 prominent bioinformatics databases. Our experiments show that our approach outperforms several state-of-the-art methods for link prediction while providing interpretability.
The graph structure of biomedical data differs from those in typical knowledge graph benchmark tasks. A particular property of biomedical data is the presence of long-range dependencies, which can be captured by patterns described as logical rules. W
One of the fundamental problems in Artificial Intelligence is to perform complex multi-hop logical reasoning over the facts captured by a knowledge graph (KG). This problem is challenging, because KGs can be massive and incomplete. Recent approaches
Despite the success of generative pre-trained language models on a series of text generation tasks, they still suffer in cases where reasoning over underlying commonsense knowledge is required during generation. Existing approaches that integrate com
This paper studies learning logic rules for reasoning on knowledge graphs. Logic rules provide interpretable explanations when used for prediction as well as being able to generalize to other tasks, and hence are critical to learn. Existing methods e
Large scale knowledge graphs (KGs) such as Freebase are generally incomplete. Reasoning over multi-hop (mh) KG paths is thus an important capability that is needed for question answering or other NLP tasks that require knowledge about the world. mh-K