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In this study, we explore quantitative correlates of qualitative human expert perception. We discover that current quality metrics and loss functions, considered for biomedical image segmentation tasks, correlate moderately with segmentation quality assessment by experts, especially for small yet clinically relevant structures, such as the enhancing tumor in brain glioma. We propose a method employing classical statistics and experimental psychology to create complementary compound loss functions for modern deep learning methods, towards achieving a better fit with human quality assessment. When training a CNN for delineating adult brain tumor in MR images, all four proposed loss candidates outperform the established baselines on the clinically important and hardest to segment enhancing tumor label, while maintaining performance for other label channels.
Objective: Medical image datasets with pixel-level labels tend to have a limited number of organ or tissue label classes annotated, even when the images have wide anatomical coverage. With supervised learning, multiple classifiers are usually needed
We propose a 4D convolutional neural network (CNN) for the segmentation of retrospective ECG-gated cardiac CT, a series of single-channel volumetric data over time. While only a small subset of volumes in the temporal sequence is annotated, we define
Development of deep learning systems for biomedical segmentation often requires access to expert-driven, manually annotated datasets. If more than a single expert is involved in the annotation of the same images, then the inter-expert agreement is no
Deep neural networks (DNNs) show promise in image-based medical diagnosis, but cannot be fully trusted since their performance can be severely degraded by dataset shifts to which human perception remains invariant. If we can better understand the dif
In many medical imaging and classical computer vision tasks, the Dice score and Jaccard index are used to evaluate the segmentation performance. Despite the existence and great empirical success of metric-sensitive losses, i.e. relaxations of these m