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We study approaches to robust model-based design of experiments in the context of maximum-likelihood estimation. These approaches provide robustification of model-based methodologies for the design of optimal experiments by accounting for the effect of the parametric uncertainty. We study the problem of robust optimal design of experiments in the framework of nonlinear least-squares parameter estimation using linearized confidence regions. We investigate several well-known robustification frameworks in this respect and propose a novel methodology based on multi-stage robust optimization. The proposed methodology aims at problems, where the experiments are designed sequentially with a possibility of re-estimation in-between the experiments. The multi-stage formalism aids in identifying experiments that are better conducted in the early phase of experimentation, where parameter knowledge is poor. We demonstrate the findings and effectiveness of the proposed methodology using four case studies of varying complexity.
We review recent literature that proposes to adapt ideas from classical model based optimal design of experiments to problems of data selection of large datasets. Special attention is given to bias reduction and to protection against confounders. Som
Many robotics domains use some form of nonconvex model predictive control (MPC) for planning, which sets a reduced time horizon, performs trajectory optimization, and replans at every step. The actual task typically requires a much longer horizon tha
We propose a new procedure for inference on optimal treatment regimes in the model-free setting, which does not require to specify an outcome regression model. Existing model-free estimators for optimal treatment regimes are usually not suitable for
Blocking is often used to reduce known variability in designed experiments by collecting together homogeneous experimental units. A common modelling assumption for such experiments is that responses from units within a block are dependent. Accounting
In this paper, we study the quantum-state estimation problem in the framework of optimal design of experiments. We first find the optimal designs about arbitrary qubit models for popular optimality criteria such as A-, D-, and E-optimal designs. We a