Blockchain technology has rapidly evolved from an enabling technology for cryptocurrencies to a potential solution to a wider range of problems found in data-centric and distributed systems. Interest in this area has encouraged many recent innovations to address challenges that traditional approaches of design have been unable to meet. Healthcare Information Systems with issues around privacy, interoperability, data integrity, and access control is potentially an area where blockchain technology may have a significant impact. Blockchain, however, is a meta-technology, combining multiple techniques, as it is often important to determine how best to separate concerns in the design and implementation of such systems. This paper proposes a layered approach for the organization of blockchain in healthcare applications. Key issues driving the adoption of this technology are explored. A model presenting the points in each layer is explored. Finally, we present an example of how the perspective we describe can improve the development of Health Information Systems.