The preparation of large, low-entropy, highly coherent ensembles of identical quantum systems is foundational for many studies in quantum metrology, simulation, and information. Here, we realize these features by leveraging the favorable properties of tweezer-trapped alkaline-earth atoms while introducing a new, hybrid approach to tailoring optical potentials that balances scalability, high-fidelity state preparation, site-resolved readout, and preservation of atomic coherence. With this approach, we achieve trapping and optical clock excited-state lifetimes exceeding $ 40 $ seconds in ensembles of approximately $ 150 $ atoms. This leads to half-minute-scale atomic coherence on an optical clock transition, corresponding to quality factors well in excess of $10^{16}$. These coherence times and atom numbers reduce the effect of quantum projection noise to a level that is on par with leading atomic systems, yielding a relative fractional frequency stability of $5.2(3)times10^{-17}~(tau/s)^{-1/2}$ for synchronous clock comparisons between sub-ensembles within the tweezer array. When further combined with the microscopic control and readout available in this system, these results pave the way towards long-lived engineered entanglement on an optical clock transition in tailored atom arrays.