Production and inventory planning have become crucial and challenging in nowadays competitive industrial and commercial sectors, especially when multiple plants or warehouses are involved. In this context, this paper addresses the complexity of uncapacitated multi-plant lot-sizing problems. We consider a multi-item uncapacitated multi-plant lot-sizing problem with fixed transfer costs and show that two of its very restricted special cases are already NP-hard. Namely, we show that the single-item uncapacitated multi-plant lot-sizing problem with a single period and the multi-item uncapacitated two-plant lot-sizing problem with fixed transfer costs are NP-hard. Furthermore, as a direct implication of the proven results, we also show that a two-echelon multi-item lot-sizing with joint setup costs on transportation is NP-hard.
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