Using a careful choice of infrared (IR) subtraction scheme, we demonstrate the cancellation of all terms with transcendental weights 0,1,2 from the finite part of the full-color two-loop four-gluon $mathcal{N}=2$ supersymmetric QCD amplitude, with $N_f$ massless supersymmetric quarks. This generalizes the previously observed cancellation of weight-2 terms in the superconformal theory, where $N_f=2N_c$ for gauge group SU$(N_c)$. The subtraction scheme follows naturally both from general IR factorization principles and from an integrand-level analysis of divergences in this amplitude. The divergences are written in terms of scalar triangle integrals whose expressions are known to all orders in the dimensional regulator $epsilon=(4-D)/2$. We also present integrated expressions for the full-color two-loop four-point amplitudes with both matter and vectors on external legs in which lower-weight terms also cancel using an appropriate IR scheme. This provides us with values for the two-loop cusp, gluonic, and quark anomalous dimensions in $mathcal{N}=2$ supersymmetric QCD, which are cross-checked between the three different amplitudes.
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