We employ a variety of symmetry breaking patterns in $SO(10)$ and $E_6$ Grand Unified Theories to demonstrate the appearance of topological defects including magnetic monopoles, strings, and necklaces. We show that independent of the symmetry breaking pattern, a topologically stable superheavy monopole carrying a single unit of Dirac charge as well as color magnetic charge is always present. Lighter intermediate mass topologically stable monopoles carrying two or three quanta of Dirac charge can appear in $SO(10)$ and $E_6$ models respectively. These lighter monopoles as well as topologically stable intermediate scale strings can survive an inflationary epoch. We also show the appearance of a novel necklace configuration in $SO(10)$ broken to the Standard Model via $SU(4)_ctimes SU(2)_Ltimes SU(2)_R$. It consists of $SU(4)_c$ and $SU(2)_R$ monopoles connected by flux tubes. Necklaces consisting of monopoles and antimonopoles joined together by flux tubes are also identified. Even in the absence of topologically stable strings, a monopole-string system can temporarily appear. This system decays by emitting gravity waves and we provide an example in which the spectrum of these waves is strongly peaked around $10^{-4}~{rm Hz}$ with $Omega_{rm gw}h^2simeq 10^{-12}$. This spectrum should be within the detection capability of LISA.
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