Sponsored search is an indispensable business model and a major revenue contributor of almost all the search engines. From the advertisers side, participating in ranking the search results by paying for the sponsored search advertisement to attract more awareness and purchase facilitates their commercial goal. From the users side, presenting personalized advertisement reflecting their propensity would make their online search experience more satisfactory. Sponsored search platforms rank the advertisements by a ranking function to determine the list of advertisements to show and the charging price for the advertisers. Hence, it is crucial to find a good ranking function which can simultaneously satisfy the platform, the users and the advertisers. Moreover, advertisements showing positions under different queries from different users may associate with advertisement candidates of different bid price distributions and click probability distributions, which requires the ranking functions to be optimized adaptively to the traffic characteristics. In this work, we proposed a generic framework to optimize the ranking functions by deep reinforcement learning methods. The framework is composed of two parts: an offline learning part which initializes the ranking functions by learning from a simulated advertising environment, allowing adequate exploration of the ranking function parameter space without hurting the performance of the commercial platform. An online learning part which further optimizes the ranking functions by adapting to the online data distribution. Experimental results on a large-scale sponsored search platform confirm the effectiveness of the proposed method.