The fragmentation of black hole containing $f(R)$ global monopole under GUP is studied. We focus on that the black hole breaks into two parts. We derive the entropies of the initial black hole and the broken parts while the generalization of Heisenbergs uncertainty principle is introduced. We find that the $f(R)$ global monopole black hole keeps stable instead of breaking because the entropy difference is negative without the generalization. The fragmentation of the black hole will happen if the black hole entropies are limited by the GUP and the considerable deviation from the general relativity leads the case that the mass of one fragmented black hole is extremely small and the other one is extremely large.