In the last years several proof of principle experiments have demonstrated the advantages of quantum technologies respect to classical schemes. The present challenge is to overpass the limits of proof of principle demonstrations to approach real applications. This letter presents such an achievement in the field of quantum enhanced imaging. In particular, we describe the realization of a sub-shot noise wide field microscope based on spatially multi-mode non-classical photon number correlations in twin beams. The microscope produces real time images of 8000 pixels at full resolution, for (500micrometers)2 field-of-view, with noise reduced to the 80% of the shot noise level (for each pixel), suitable for absorption imaging of complex structures. By fast post-elaboration, specifically applying a quantum enhanced median filter, the noise can be further reduced (less than 30% of the shot noise level) by setting a trade-off with the resolution, demonstrating the best sensitivity per incident photon ever achieved in absorption microscopy.
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