We developed a novel approach based on a generalization of factorization and nuclear spectral functions, allowing for a consistent treatment of the amplitudes involving one- and two-nucleon currents, whose contribution to the nuclear electromagnetic response in the transverse channel is known to be significant. We report the results of calculations of the inclusive electron-carbon cross section, showing that the inclusion of processes involving two-nucleon currents appreciably improves the agreement between theory and data in the dip region, between the quasi elastic and $Delta$-production peaks. The implications for the analysis of neutrino-nucleus cross sections are discussed.
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