This paper reports the most recent measurements of single top quark production performed by CDF and D0 collaborations in proton-antiproton collisions at Tevatron. Events are selected in the lepton+jets final state by CDF and D0 and in the missing transverse energy plus jets final state by CDF. The small single top signal in s-channel, t-channel and inclusive s+t channel is separated from the large background by using different multivariate techniques. We also present the most recent results on extraction of the CKM matrix element $|V_{tb}|$ from the single top quark cross section.
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