It is predicted that in force microscopy the quantum fluctuations responsible for the Casimir force can be directly observed as temperature-independent force fluctuations having spectral density $9pi/(40ln(4/e)) hbar delta k$, where $hbar$ is Plancks constant and $delta k$ is the observed change in spring constant as the microscope tip approaches a sample. For typical operating parameters the predicted force noise is of order $10^{-18}$ Newton in one Hertz of bandwidth. The Second Law is respected via the fluctuation-dissipation theorem. For small tip-sample separations the cantilever damping is predicted to increase as temperature is reduced, a behavior that is reminiscent of the Kondo effect.