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Recent work on mutation-selection models has revealed that, under specific assumptions on the fitness function and the mutation rates, asymptotic estimates for the leading eigenvalue of the mutation-reproduction matrix may be obtained through a low-dimensional maximum principle in the limit N to infinity (where N is the number of types). In order to extend this variational principle to a larger class of models, we consider here a family of reversible N by N matrices and identify conditions under which the high-dimensional Rayleigh-Ritz variational problem may be reduced to a low-dimensional one that yields the leading eigenvalue up to an error term of order 1/N. For a large class of mutation-selection models, this implies estimates for the mean fitness, as well as a concentration result for the ancestral distribution of types.
Tuffley and Steel (1997) proved that Maximum Likelihood and Maximum Parsimony methods in phylogenetics are equivalent for sequences of characters under a simple symmetric model of substitution with no common mechanism. This result has been widely cit
Cooperation is prevalent in nature, not only in the context of social interactions within the animal kingdom, but also on the cellular level. In cancer for example, tumour cells can cooperate by producing growth factors. The evolution of cooperation
The coexistence between different types of templates has been the choice solution to the information crisis of prebiotic evolution, triggered by the finding that a single RNA-like template cannot carry enough information to code for any useful replic
A matrix Lie algebra is a linear space of matrices closed under the operation $ [A, B] = AB-BA $. The Lie closure of a set of matrices is the smallest matrix Lie algebra which contains the set. In the context of Markov chain theory, if a set of rate
It was recently proposed to encode the one-sided exponential source X via K parallel channels, Y1, ..., YK , such that the error signals X - Yi, i = 1,...,K, are one-sided exponential and mutually independent given X. Moreover, it was shown that the