We study the possible relationship between the saturation properties of nuclear matter and the inclusion of non-locality in the nucleon-nucleon interaction. To this purpose we compute the saturation curve of nuclear matter within the Bethe-Brueckner-Goldstone theory using a recently proposed realistic non-local potential, and compare it with the corresponding curves obtained with a purely local realistic interaction (Argonne v$_{18}$) and the most recent version of the one-boson exchange potential (CD Bonn). We find that the inclusion of non-locality in the two-nucleon bare interaction strongly affects saturation, but it is unable to provide a consistent description of few-body nuclear systems and nuclear matter.