In this note, we announce the first results on quasi-isometric rigidity of non-nilpotent polycyclic groups. In particular, we prove that any group quasi-isometric to the three dimenionsional solvable Lie group Sol is virtually a lattice in Sol. We prove analogous results for groups quasi-isometric to $R ltimes R^n$ where the semidirect product is defined by a diagonalizable matrix of determinant one with no eigenvalues on the unit circle. Our approach to these problems is to first classify all self quasi-isometries of the solvable Lie group. Our classification of self quasi-isometries for $R ltimes R^n$ proves a conjecture made by Farb and Mosher in [FM4]. Our techniques for studying quasi-isometries extend to some other classes of groups and spaces. In particular, we characterize groups quasi-isometric to any lamplighter group, answering a question of de la Harpe [dlH]. Also, we prove that certain Diestel-Leader graphs are not quasi-isometric to any finitely generated group, verifying a conjecture of Diestel and Leader from [DL] and answering a question of Woess from [SW],[Wo1]. We also prove that certain non-unimodular, non-hyperbolic solvable Lie groups are not quasi-isometric to finitely generated groups. The results in this paper are contributions to Gromovs program for classifying finitely generated groups up to quasi-isometry [Gr2]. We introduce a new technique for studying quasi-isometries, which we refer to as coarse differentiation.