Seiberg-Witten solutions of four-dimensional supersymmetric gauge theories possess rich but involved integrable structures. The goal of this paper is to show that an isomonodromy problem provides a unified framework for understanding those various features of integrability. The Seiberg-Witten solution itself can be interpreted as a WKB limit of this isomonodromy problem. The origin of underlying Whitham dynamics (adiabatic deformation of an isospectral problem), too, can be similarly explained by a more refined asymptotic method (multiscale analysis). The case of $N=2$ SU($s$) supersymmetric Yang-Mills theory without matter is considered in detail for illustration. The isomonodromy problem in this case is closely related to the third Painleve equation and its multicomponent analogues. An implicit relation to $ttbar$ fusion of topological sigma models is thereby expected.
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