We describe the first lattice determination of the strong coupling constant with 3 flavors of dynamical quarks. The method follows previous analyses in using a perturbative expansion for the plaquette and Upsilon spectroscopy to set the scale. Using dynamical configurations from the MILC collaboration with 2+1 flavors of dynamical quarks we are able to avoid previous problems of having to extrapolate to 3 light flavors from 0 and 2. Our results agree with our previous work: alpha_s_MSbar(M_Z) = 0.121(3).
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