We discuss the first applications of our newly developed Monte Carlo event generator SOPHIA to multiparticle photoproduction of relativistic protons with thermal and power law radiation fields. The measured total cross section is reproduced in terms of excitation and decay of baryon resonances, direct pion production, diffractive scattering, and non-diffractive multiparticle production. Non--diffractive multiparticle production is described using a string fragmentation model. We demonstrate that the widely used `$Delta$--approximation for the photoproduction cross section is reasonable only for a restricted set of astrophysical applications. The relevance of this result for cosmic ray propagation through the microwave background and hadronic models of active galactic nuclei and gamma-ray bursts is briefly discussed.
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