We present UBVRIz optical images of the 0.32 square degree Extended Hubble Deep Field South. This is one of four fields comprising the MUSYC survey, which is optimized for the study of galaxies at z=3, AGN demographics, and Galactic structure. We calculate corrected aperture photometry and its uncertainties and find through tests that these provide a significant improvement upon standard techniques. Our photometric catalog of 62968 objects is complete to a total magnitude of R_AB=25. We select z=3 Lyman break galaxy (LBG) candidates from their UVR colors and find a sky surface density of 1.4/sq. arcmin and an angular correlation function w(theta) = 2.3+-1.0 theta^{-0.8}. (Abridged)