Continuous-variable quantum key distribution (CV-QKD) with discrete modulation has received widespread attentions because of its experimental simplicity, lower-cost implementation and ease to multiplex with classical optical communication. Recently, some inspiring numerical methods have been applied to analyse the security of discrete-modulated CV-QKD against collective attacks, which promises to obtain considerable key rate over one hundred kilometers of fiber distance. However, numerical methods require up to ten minutes to calculate a secure key rate one time using a high-performance personal computer, which means that extracting the real-time secure key rate is impossible for discrete-modulated CV-QKD system. Here, we present a neural network model to quickly predict the secure key rate of homodyne detection discrete-modulated CV-QKD with good accuracy based on experimental parameters and experimental results. With the excess noise of about $0.01$, the speed of our method is improved by about seven orders of magnitude compared to that of the conventional numerical method. Our method can be extended to quickly solve complex security key rate calculation of a variety of other unstructured quantum key distribution protocols.
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