Tracking the 6D pose of objects in video sequences is important for robot manipulation. Most prior efforts, however, often assume that the target objects CAD model, at least at a category-level, is available for offline training or during online template matching. This work proposes BundleTrack, a general framework for 6D pose tracking of novel objects, which does not depend upon 3D models, either at the instance or category-level. It leverages the complementary attributes of recent advances in deep learning for segmentation and robust feature extraction, as well as memory-augmented pose graph optimization for spatiotemporal consistency. This enables long-term, low-drift tracking under various challenging scenarios, including significant occlusions and object motions. Comprehensive experiments given two public benchmarks demonstrate that the proposed approach significantly outperforms state-of-art, category-level 6D tracking or dynamic SLAM methods. When compared against state-of-art methods that rely on an object instance CAD model, comparable performance is achieved, despite the proposed methods reduced information requirements. An efficient implementation in CUDA provides a real-time performance of 10Hz for the entire framework. Code is available at: https://github.com/wenbowen123/BundleTrack